What is leptin?

Leptin is a hormone released from the fat cells in adipose tissue that sends signals to the hypothalamus in the brain that help regulate food intake and energy expenditure. The primary role of leptin is to help the body maintain its weight. It also modulates insulin sensitivity, with higher levels of leptin promoting insulin resistance and perpetuating a positive feedback loop. Studies have been conducted assessing leptin levels in the peripheral blood of people with bipolar disorder, with conflicting results.

What is the evidence for changes in leptin in people with bipolar disorder?

Moderate quality evidence suggests no differences in leptin levels between people with bipolar disorder and controls, regardless of bipolar mood state.

Low quality evidence is unclear of the association between antipsychotic use and leptin levels in people with bipolar disorder.

April 2019

Last updated at: 2:22 am, 9th April 2019
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