Familial factors

What is familial risk?

Many disorders are the result of interaction between susceptibility genes and environmental influences. One example is cardiovascular disease; people with a family history of cardiovascular disease are more susceptible to heart problems, and environmental influences, such as diet, can increase this risk. Bipolar disorder is also a complex disorder that can arise from both genetic and environmental influences.

What is the evidence for familial risk?

Moderate to low quality evidence suggests a medium-sized increased risk of bipolar disorder in the offspring of people with bipolar disorder. There were also small effects of increased risk of depressive, anxiety, disruptive, substance use and attention-hyperactivity deficit disorders.

April 2019

Last updated at: 11:17 pm, 9th April 2019
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Fact Sheet Technical Commentary

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