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Adenosine modulators

What are adenosine modulators?

Adenosine modulates dopamine and glutamine which are both implicated in schizophrenia’s pathophysiology; therefore adenosine modulators may be useful adjunctive treatments for schizophrenia. Allopurinol is used for the treatment of gout and hyperuricemia; it inhibits purine degradation and subsequently increases adenosine levels. Dipyridamole and propentofylline inhibit cellular reuptake of adenosine and increases extracellular adenosine
concentration.

What is the evidence for adenosine modulators?

Moderate to low quality evidence suggests adjunctive adenosine modulators (particularly dipyridamole and propentofylline) may improve symptoms, particularly positive symptoms, in people with schizophrenia.

 

June 2016

Page last updated: 4:03  3 August 2018

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