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Cholinergic medication

What are cholinergic medications?

Cholinergic medications have been prescribed for tardive dyskinesia, which is a common side effect of antipsychotics, involving repetitive, involuntary movements most commonly occurring around the mouth and face. The cause of tardive dyskinesia is largely unknown, however some theories proposing the cause implicates brain cells that utilise the acetylcholine neurotransmitter. Older cholinergic medications (such as those included in this summary) can have adverse effects themselves, while newer compounds have less severe side effects, but they have not yet been studied in relation to tardive dyskinesia.

What is the evidence on cholinergic medications?

Moderate to low quality evidence suggests no benefit of cholinergic medications compared to placebo for tardive dyskinesia. There were also no benefits for global state, mental state, or adverse effects.

 

June 2016

Page last updated: 3:05  22 August 2017

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