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Serotonin modulators

What are serotonin modulators? 

Serotonin is a neurotransmitter. Atypical antipsychotics are thought to have some affinity for serotonin 5-HT receptors, for example clozapine, quetiapine, and olanzapine, among others. This suggests a potential for the use of serotonin-specific medications in the treatment of schizophrenia.

What is the evidence for adjunctive serotonin modulators?

Moderate quality evidence suggests a small effect of adjunctive buspirone, tandospirone, tropisetron, or mianserin for improving positive symptoms, and a medium-sized effect of buspirone or tandospirone for improving overall symptoms. Moderate to low quality evidence suggests a large effect for overall and negative symptoms with adjunctive granisetron, ondansetron, or tropisetron. No benefits are reported for cognitive functioning.


August 2016

Page last updated: 4:01  22 August 2017

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