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Melatonin

How is melatonin relevant to schizophrenia?

Melatonin is a hormone primarily synthesised by the pineal gland. Secretion of melatonin by the pineal gland shows a circadian rhythm synchronised to the light-dark cycle. Melatonin has been reported to be involved in various important biological functions in the body: sleep regulation, circadian rhythm, immune modulation, reproduction, anti-inflammation, antioxidant, and energy metabolism. Various studies have reported the beneficial effects of taking melatonin for improving metabolic problems; problems often observed in people on antipsychotic medications.

What is the evidence for melatonin levels?

Moderate quality evidence finds reduced midnight melatonin plasma levels in people with schizophrenia compared to controls.

October 2020

Last updated at: 11:15 pm, 28th October 2020
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Fact Sheet Technical Commentary

NeuRA Libraries

Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.