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How is neutropenia related to schizophrenia?

Clozapine is a second generation antipsychotic often administered when other antipsychotics are not affective. However, neutropenia is a potential side effect of clozapine use. Neutropenia can result in death and involves low levels of neutrophils; the white blood cells that help the body fight infection.

What is the evidence for neutropenia?

Moderate quality evidence suggests the incidence of mild neutropenia in people taking clozapine is around 3.8%, and the incidence of severe neutropenia is around 0.9%. Death from neutropenia is rare at around 0.013%.

November 2019

Last updated at: 4:54 am, 26th November 2019
To view documentation related to this topic download the files below
Fact Sheet Technical Commentary

NeuRA Libraries

Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.