What is hyponatraemia?

Hyponatraemia is an imbalance of electrolytes in the blood serum, typically involving reduced salt (sodium) levels. This usually occurs through excessive water retention diluting the salt content of the blood in combination with increased sodium excretion in the kidneys. Mild hyponatraemia does not have obvious symptoms, however when sodium levels drop dangerously low they can cause muscle cramps, lethargy, and delirium; eventually leading to convulsions, which can be fatal. Hyponatraemia can occur as a side effect of many medications, and may include antipsychotics.

What is the evidence for hyponatraemia?

Low quality evidence is unclear as to risk of hyponatraemia following any specific antipsychotic medication.

March 2019

Last updated at: 1:27 am, 21st March 2019
To view documentation related to this topic download the files below
Fact Sheet Technical Commentary

NeuRA Libraries

Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.