Topics tagged with "Aripiprazole"

Antipsychotic polypharmacy

What is antipsychotic polypharmacy? Antipsychotic combination treatment, also called antipsychotic polypharmacy, has been utilised in clinical practice for patients who are unresponsive or partially responsive to antipsychotic monotherapies. Please also see the treatments for medication-resistant schizophrenia topic for augmentation with other pharmaceutical agents. What is the evidence for antipsychotic polypharmacy? Moderate to high quality evidence suggests a small effect of less discontinuation for any reason, and moderate quality evidence suggests better clinical response with antipsychotic polypharmacy versus monotherapy. Moderate quality evidence suggests antipsychotic polypharmacy is most often associated with the use of first generation antipsychotics, inpatient status, and a diagnosis…

Aripiprazole

What is aripiprazole? Second generation antipsychotics (sometimes referred to as ‘atypical’ antipsychotics) such as aripiprazole are a newer class of antipsychotic medication than first generation ‘typical’ antipsychotics. Second generation antipsychotics are effective for the positive symptoms of schizophrenia. It is sometimes claimed that they are more effective than first generation antipsychotics in treating the negative symptoms of schizophrenia. Negative symptoms include a lack of ordinary mental activities such as emotional expression, social engagement, thinking and motivation, whereas positive symptoms include the experiences of perceptual abnormalities (hallucinations) and fixed, false, irrational beliefs (delusions). Second generation antipsychotics may also cause less extra-pyramidal…

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