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Topics tagged with "Clozapine"


How is neutropenia related to schizophrenia? Clozapine is a second generation antipsychotic often administered when other antipsychotics are not affective. However, neutropenia is a potential side effect of clozapine use. Neutropenia can result in death and involves low levels of neutrophils; the white blood cells that help the body fight infection. What is the evidence for neutropenia? Moderate quality evidence suggests the incidence of mild neutropenia in people taking clozapine is around 3.8%, and the incidence of severe neutropenia is around 0.9%. Death from neutropenia is rare at around 0.013%. November 2019

Antipsychotic polypharmacy

What is antipsychotic polypharmacy? Antipsychotic combination treatment, also called antipsychotic polypharmacy, has been utilised in clinical practice for patients who are unresponsive or partially responsive to antipsychotic monotherapies. Please also see the treatments for medication-resistant schizophrenia topic for augmentation with other pharmaceutical agents. What is the evidence for antipsychotic polypharmacy? Moderate to high quality evidence finds a medium-sized improvement in overall symptoms and a small improvement in clinical response with antipsychotic polypharmacy vs. monotherapy. There is also less discontinuation for any reason with antipsychotic polypharmacy. Moderate quality evidence finds antipsychotic polypharmacy is most often associated with the use of first-generation…


What is clozapine? Second generation antipsychotics (sometimes referred to as ‘atypical’ antipsychotics) such as clozapine are a newer class of antipsychotic medication than first generation ‘typical’ antipsychotics. Second generation antipsychotics are effective for the positive symptoms of schizophrenia. It is sometimes claimed that they are more effective than first generation antipsychotics in treating the negative symptoms of schizophrenia, although the evidence for this is weak. Negative symptoms include a lack of ordinary mental activities such as emotional expression, social engagement, thinking and motivation, whereas positive symptoms include the experiences of perceptual abnormalities (hallucinations) and fixed, false, irrational beliefs (delusions). Second…

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