Topics tagged with "First-episode"

Therapies for first-episode bipolar disorder

What is first-episode bipolar disorder? The course of bipolar disorder and its treatment response tends to worsen over time, highlighting the importance of early intervention. As bipolar disorder cannot be diagnosed on the basis of depression alone, the onset of a manic episode may indicate an underlying bipolar disorder. Interventions for first-episode psychosis or depression have begun to be extended to those with bipolar disorder, however such interventions need to be tailored to suit people with first-episode bipolar disorder, and research is sparse for these patients. What is the evidence for psychosocial treatments for first-episode bipolar disorder? Low quality evidence…

Bipolar disorder diagnosis

Cognition in first-episode bipolar disorder

What is cognition in first-episode bipolar disorder? Cognitive dysfunction is a common feature of bipolar disorder that exists across a number of cognitive domains and usually persists in remission. It is unclear whether cognitive deficits are apparent prior to the onset of bipolar disorder or whether they develop during the course of the illness. Assessing cognitive ability in people with a first-episode of bipolar disorder helps determine whether cognitive deficits were apparent prior to illness onset. What is the evidence for cognition in first-episode bipolar disorder? Compared to people without bipolar disorder (controls), high quality evidence shows medium-sized effects of…


Early detection

Why is early detection of bipolar disorder important? Early detection of bipolar disorder can prevent or delay the onset of the disorder, and improve clinical outcomes in people who develop it. What is the evidence regarding early detection of bipolar disorder? Moderate to high quality evidence suggests large effects of having psychotic symptoms or a family history of bipolar disorder as risk factors for transition to bipolar disorder in people with major depression. There was a medium-sized effect of higher risk of transition to bipolar disorder with early age of onset of depression, and a small effect of having a…

Medications for first-episode psychosis

What is first-episode psychosis? People with a first episode of psychosis experience distressing symptoms such as unusual beliefs or abnormal behaviour (positive symptoms) and/or withdrawal or loss of interest in work or school (negative symptoms). Early intervention programs for schizophrenia and psychosis often combine many elements comprising both pharmaceutical and psychosocial therapies, and may involve enriched therapies that are tailored to an individual’s needs. The conclusions presented here are based on group data, and as such individual treatment programs need to be tailored by trained clinicians. Individual response to treatment can vary in terms of both symptoms and adverse effects….

First-episode psychosis

What are outcomes for people with first-episode psychosis or high-risk mental states? After being identified as having high-risk mental states, or after an initial diagnosis of psychosis, relevant outcomes over the years following include transition to psychosis or schizophrenia, symptom severity, recovery and remission, relapse, employment, functioning, relationships, and quality of life. Investigating these outcomes and the factors influencing them provides insight into early treatment strategies. What is the evidence for outcomes in people with first-episode psychosis or high-risk mental states? Moderate quality evidence suggests up to 80% of people have good or intermediate outcomes following a first episode of…

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