Herbal treatments have been suggested as possible adjunctive therapies for people with bipolar disorder who have inadequate response to their usual medications. Herbal treatments include traditional Chinese medicines, gingko biloba, folate and inositol.

What is the evidence for herbal treatments?

Moderate to low quality evidence finds adjunctive folate may be helpful for mania but not for depression, however adjunctive coenzyme Q10 may improve depression symptoms. There is also potential benefit of adjunctive micronutrients (EMPowerplus) for clinical improvement. There is no evidence of any benefit of adjunctive inositol for depression.

November 2021

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