Topics tagged with "Schizophrenia antipsychotic treatments"

Constipation

How is constipation related to schizophrenia? Some antipsychotics cause constipation. Moreover, people with schizophrenia often have pre-existing factors that increase this risk, including sedentary lifestyle, obesity, reduced fibre intake, and dehydration. Constipation can lead to gastrointestinal problems and even death. This topic assesses the risk of constipation as a side effect of antipsychotic use. What is the evidence for constipation in people with schizophrenia? Moderate to low quality evidence suggests the overall prevalence of constipation with clozapine use is around 30%, and around 40% in inpatient settings. Moderate to high quality evidence suggests a medium-sized effect of clozapine causing higher…

Mosapramine

What is mosapramine? Second generation antipsychotics (sometimes referred to as ‘atypical’ antipsychotics) such as mosapramine are a newer class of antipsychotic medication than first generation ‘typical’ antipsychotics. Second generation antipsychotics are effective for the positive symptoms of schizophrenia. It is sometimes claimed that they are more effective than first generation antipsychotics in treating the negative symptoms of schizophrenia, although the evidence for this is weak. Negative symptoms include a lack of ordinary mental activities such as emotional expression, social engagement, thinking and motivation, whereas positive symptoms include the experiences of perceptual abnormalities (hallucinations) and fixed, false, irrational beliefs (delusions). Second…

Clocapramine

What is clocapramine? Second generation antipsychotics (sometimes referred to as ‘atypical’ antipsychotics) such as clocapramine are a newer class of antipsychotic medication than first generation ‘typical’ antipsychotics. Second generation antipsychotics are effective for the positive symptoms of schizophrenia. It is sometimes claimed that they are more effective than first generation antipsychotics in treating the negative symptoms of schizophrenia, although the evidence for this is weak. Negative symptoms include a lack of ordinary mental activities such as emotional expression, social engagement, thinking and motivation, whereas positive symptoms include the experiences of perceptual abnormalities (hallucinations) and fixed, false, irrational beliefs (delusions). Second…

Second versus second generation

What are second generation antipsychotics? Second generation ‘atypical’ antipsychotics are a newer class of antipsychotic than first generation ‘atypical’ antipsychotics. Both are effective for the positive symptoms of schizophrenia, including the experiences of perceptual abnormalities (hallucinations) and fixed, false, irrational beliefs (delusions). It is sometimes claimed that they are more effective than first generation antipsychotics in treating the negative symptoms of schizophrenia. Negative symptoms include a lack of ordinary mental activities such as emotional expression, social engagement, thinking and motivation. What is the evidence for second generation antipsychotics? Moderate to high quality evidence suggests olanzapine may be superior to aripiprazole,…

All antipsychotics versus placebo

What are antipsychotics? This topic includes both first and second generation antipsychotics. Antipsychotics are effective for the symptoms of schizophrenia. Positive symptoms include the experiences of perceptual abnormalities (hallucinations) and fixed, false, irrational beliefs (delusions). Negative symptoms include a lack of ordinary mental activities such as emotional expression, social engagement, and motivation. Antipsychotics can also cause side effects. These include extrapyramidal symptoms such as dyskinesias (repetitive, involuntary, and purposeless body or facial movements), Parkinsonism (cogwheel muscle rigidity, pill-rolling tremor and reduced or slowed movements), akathisia (motor restlessness, especially in the legs, and resembling agitation), and dystonias (muscle contractions causing unusual…

First versus second generation

What are first and second generation antipsychotics? First generation ‘typical’ antipsychotics are an older class of antipsychotic than second generation ‘atypical’ antipsychotics. First generation antipsychotics are used primarily to treat positive symptoms such as hallucinations and delusions. Second generation antipsychotics are also effective for the positive symptoms of schizophrenia, and it is sometimes claimed that they are more effective than first generation antipsychotics in treating the negative symptoms of schizophrenia. Negative symptoms include a lack of ordinary mental activities such as emotional expression, social engagement, thinking and motivation. High potency first generation antipsychotics usually have high affinity for the dopamine…

Perospirone

What is perospirone? Second generation antipsychotics (sometimes referred to as ‘atypical’ antipsychotics) such as perospirone are a newer class of antipsychotic medication than first generation ‘typical’ antipsychotics. Second generation antipsychotics are effective for the positive symptoms of schizophrenia. It is sometimes claimed that they are more effective than first generation antipsychotics in treating the negative symptoms of schizophrenia. Negative symptoms include a lack of ordinary mental activities such as emotional expression, social engagement, thinking and motivation, whereas positive symptoms include the experiences of perceptual abnormalities (hallucinations) and fixed, false, irrational beliefs (delusions). Second generation antipsychotics may also cause less extra-pyramidal…

Asenapine

What is asenapine? Second generation antipsychotics (sometimes referred to as ‘atypical’ antipsychotics) such as asenapine are a newer class of antipsychotic medication than first generation ‘typical’ antipsychotics. Second generation antipsychotics are effective for the positive symptoms of schizophrenia. It is sometimes claimed that they are more effective than first generation antipsychotics in treating the negative symptoms of schizophrenia, although the evidence for this is weak. Negative symptoms include a lack of ordinary mental activities such as emotional expression, social engagement, thinking and motivation, whereas positive symptoms include the experiences of perceptual abnormalities (hallucinations) and fixed, false, irrational beliefs (delusions). Second…

Blonanserin

What is blonanserin? Second generation antipsychotics (sometimes referred to as ‘atypical’ antipsychotics) such as blonanserin are a newer class of antipsychotic medication than first generation ‘typical’ antipsychotics. Second generation antipsychotics are effective for the positive symptoms of schizophrenia. It is sometimes claimed that they are more effective than first generation antipsychotics in treating the negative symptoms of schizophrenia. Negative symptoms include a lack of ordinary mental activities such as emotional expression, social engagement, thinking and motivation, whereas positive symptoms include the experiences of perceptual abnormalities (hallucinations) and fixed, false, irrational beliefs (delusions). Second generation antipsychotics may also cause less extra-pyramidal…

Amisulpride

What is amisulpride? Second generation antipsychotics (sometimes referred to as ‘atypical’ antipsychotics) such as amisulpride are a newer class of antipsychotic medication than first generation ‘typical’ antipsychotics. Second generation antipsychotics are effective for the positive symptoms of schizophrenia. It is sometimes claimed that they are more effective than first generation antipsychotics in treating the negative symptoms of schizophrenia. Negative symptoms include a lack of ordinary mental activities such as emotional expression, social engagement, thinking and motivation, whereas positive symptoms include the experiences of perceptual abnormalities (hallucinations) and fixed, false, irrational beliefs (delusions). Second generation antipsychotics may also cause less extra-pyramidal…

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