Topics tagged with "Schizophrenia treatment resistance"

Treatments for medication-resistant schizophrenia

What is medication resistance?  Antipsychotic medications provide symptom respite and improvement in quality of life for many people with schizophrenia. However, for a subset of people with schizophrenia, antipsychotic medications do not provide adequate relief from symptoms. Treatment-resistant schizophrenia has many definitions that vary depending on the individual study, but a broad definition includes those patients whose symptoms have not responded to antipsychotic medications, or only partially responded. What is the evidence for medication resistance? Moderate to high quality evidence finds a general pattern of superiority of clozapine, olanzapine or risperidone over other antipsychotics for improving symptoms in people with…


What is treatment resistance? Antipsychotic medications generally provide symptom relief and improvement in quality of life for people with schizophrenia. However, some people with schizophrenia find that antipsychotic medications do not provide adequate relief from their symptoms. This topic covers the course and outcome of treatment resistance, please see the treatment topics for information on potential treatments for treatment-resistant schizophrenia. What is the evidence on treatment-resistant schizophrenia? Moderate quality evidence finds people with treatment-resistant schizophrenia have higher rates of smoking, alcohol or substance abuse, suicide ideation, more glutamatergic abnormalities, and more familial loading for schizophrenia than people with treatment-responsive schizophrenia….

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