Autoimmune disease

What is autoimmune disease in bipolar disorder?

Autoimmune disease occurs when the body attacks its own tissues due to an abnormally functioning immune system. Common autoimmune diseases include systemic lupus erythematosus, rheumatoid arthritis, psoriasis, multiple sclerosis, ulcerative colitis, Crohn’s disease, ankylosing spondylitis, pemphigus, and Sjogren’s syndrome.

What is the evidence for comorbid autoimmune disease?

Moderate quality evidence finds a significant, small increased rate of bipolar disorder in people with autoimmune disease, particularly sicca syndrome, systemic lupus erythematosus, and psoriasis.

Moderate to low quality evidence finds the prevalence of bipolar disorder in people with multiple sclerosis is ~6%. This finding is based on one study conducted in England, so may not be applicable to other populations.

October 2021

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Last updated at: 4:17 am, 21st October 2021
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Fact Sheet Technical Commentary

NeuRA Libraries

Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.