What are analeptics? 

A supplementary, or adjunctive, treatment is administered in conjunction with a patient’s ongoing antipsychotic therapy. Analeptics, such as modafinil, have been suggested as potential adjunctive treatments for schizophrenia. Modafinal is a wake-promoting drug (mechanisms of action unknown) which is thought to help with the sedation side-effects of antipsychotics.

What is the evidence on adjunctive analeptics?

Moderate to high quality evidence suggests adjunctive modafinil can improve negative symptoms, but not positive symptoms or cognition, with no more adverse effects than placebo. Lower quality evidence also finds no differences in global state, quality of life, hospitalisation rates, or study retention.

October 2020

Last updated at: 3:07 am, 7th October 2020
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