Motor dysfunction

What are antecedents of schizophrenia?

Antecedents such as motor dysfunction are subtle deviations in development that may become evident during childhood or adolescence. The presence of these deviations may foreshadow the later development of schizophrenia, however most children who exhibit these antecedents do not develop the disorder. Studies exploring antecedents are ideally based on representative, population-based samples that follow the group from birth through childhood and adolescence to adulthood. These studies can provide unique insights into the changes in developmental trajectories that may be associated with schizophrenia.

What is the evidence for motor dysfunction as an antecedent of schizophrenia?

High quality evidence finds schizophrenia in adulthood is associated with a medium-sized effect of delay in walking unsupported in infancy, and small effects of delays in standing and sitting unsupported in infancy.

High quality evidence suggests youth ≤ 16 years who developed schizophrenia in adulthood were more likely to display deficits in motor function than youth who did not develop the disorder (medium-sized effect).

March 2022

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Last updated at: 3:45 pm, 29th March 2022
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