What is zonisamide treatment for bipolar disorder?

Zonisamide is an anticonvulsant used primarily in the treatment of seizure disorders such as epilepsy. Anticonvulsant medications influence the actions of neurotransmitters leading to a decrease in brain cell (neuron) excitability. In bipolar disorder, zonisamide is used mainly for the treatment of depression.

What is the evidence for zonisamide?

Moderate to low quality evidence suggests zonisamide may be effective for general clinical improvement and depression, however, when compared to placebo there were no differences between groups in mania, hypomania, or mixed symptoms.

November 2021

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Last updated at: 1:25 pm, 15th February 2022
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