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Insulin-like growth factor

What is insulin-like growth factor-1 in bipolar disorder?

Insulin-like growth factor-1 (IGF-1) is a 70-amino acid peptide, primarily produced in the central nervous system and peripheral tissues such as the liver, and regulated via growth hormone secretion. IGF-1 interacts with the central nervous system under conditions of neuroinflammation and neurodegeneration. It also helps in neurogenesis, myelination, remyelination, neuromodulation, and synaptogenesis, which are all impaired in affective disorders, including bipolar disorder.

What is the evidence for changes in insulin-like growth factor-1 in people with bipolar disorder?

Moderate quality evidence finds increased peripheral IGF-1 levels in people with bipolar disorder or major depression compared to controls.

December 2021

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Last updated at: 6:31 pm, 9th December 2021
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Fact Sheet Technical Commentary

NeuRA Libraries

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