Glutamatergic modulators

What are glutamatergic modulators (D-cycloserine) for PTSD?

Glutamate receptor modulators have been suggested as an adjunctive treatment to psychological exposure therapies when individuals have sub-optimal responses to these therapies. D-cycloserine is a partial N-methyl-D-aspartate (NMDA) agonist that stimulates NMDA glutamate synapses involved in emotional learning and strengthens the fear extinction learning that takes place in exposure-based treatments.

What is the evidence on D-cycloserine for PTSD?

Moderate to low quality evidence finds no significant improvement in PTSD symptoms with D-cycloserine plus exposure-based treatment compared to placebo plus exposure-based treatment. There may be some improvement in people on serotonin reuptake inhibitor (SSRI) antidepressants, in people with co-occurring anxiety disorders, in people receiving more therapy sessions, and in people given earlier and greater D-cycloserine doses.

August 2021

Image: ©Sergey Tarasov-

Last updated at: 4:04 am, 15th October 2021
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NeuRA Libraries

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