Psychopathology in relatives
How is psychopathology relevant to relatives of people with schizophrenia?
Due to the significant genetic loading of schizophrenia, first-degree relatives may also show signs of psychopathology. This could include schizophrenia, bipolar disorder or other mental disorders.
What is the evidence regarding psychopathology in relatives?
Moderate to high quality evidence finds no significant increases in anxiety disorders in offspring of people with schizophrenia.
Moderate to low quality evidence also finds no significant increases in disruptive behavioural disorders in offspring of people with schizophrenia.
No systematic reviews were identified that assessed psychopathology in other family members.
April 2022
Image: ©kentoh – stock.adobe.com
Last updated at: 4:16 pm, 31st March 2022
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Antecedents
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- Psychotic relapse
- Quality of care
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- Sex differences
- Smoking
- Stigma and attitudes towards mental health
- Suicide and self-harm
- Treatment adherence
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- Insights for families
-
Physical features
-
Functional changes
- Body functioning
-
Biochemical changes
- Brain pH and lactate
- cAMP
- Cholesterol
- Dopamine
- Endocannabinoids
- GABA
- Hormonal changes
- Hypothalamic-pituitary-adrenal axis
- Infectious agents
- Inflammation and the immune system
- Lipids
- Neurometabolites
- Neurotrophins
- Nitric oxide
- NMDA receptor function
- Oxidative stress
- S100 Proteins
- Serotonin
- Synaptic proteins
- Trace elements
- Vascular endothelial growth factor
- Vitamin B
- Vitamin D
- Cerebral blood flow and metabolism
- Electrophysiology
- Structural changes
- Brain regions
-
Functional changes
-
Co-occurring conditions
- Mental disorders
-
Physical disorders
- Auditory system dysfunction
- Autoimmune diseases
- Blood disorders
- Cancer
- Cerebrovascular disease
- Dementia
- Dental disease
- Diabetes
- Digestive disorders
- Epilepsy
- Heart disease
- Infectious diseases
- Metabolic syndrome
- Musculoskeletal and connective tissues
- Obesity
- Optical alterations
- Peripheral vascular disease
- Polycistic ovary syndrome
- Postoperative complications
- Reproductive and urological disorders
- Respiratory system dysfunction
- Sexual dysfunction
- Skin disorders
- Sleep apnea
- Thyroid disorders
- Underweight
- Venous thromboembolism
- Substance use
-
Incidence and prevalence
- General
- Incidence
-
Prevalence
- Prevalence in children
- Prevalence in elderly people
- Prevalence in forensic settings
- Prevalence in homeless populations
- Prevalence in indigenous populations
- Prevalence in inpatients
- Prevalence in males vs. females
- Prevalence in migrants
- Prevalence in refugees
- Prevalence in veterans and conflict settings
- Spatial variation in prevalence
- Worldwide prevalence
- General information
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Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.