Rheumatoid arthritis
How is rheumatoid arthritis related to risk for bipolar disorder?
Rheumatoid arthritis is a common systemic inflammatory disorder primarily affecting synovial joints. Peripheral inflammation can up-regulate neuroinflammation, inducing neurological damage that can affect mood and cognition. Chronic neuroinflammation has been proposed to be a contributory factor in the development of bipolar disorder, with studies demonstrating elevated inflammatory markers in people with the disorder.
What is the evidence for rheumatoid arthritis?
Moderate quality evidence finds a medium-sized increased risk of bipolar disorder in people with rheumatoid arthritis compared to people without rheumatoid arthritis.
October 2021
Image: ©horillaz@Photo3D – stock.adobe.com
Last updated at: 4:14 pm, 21st April 2022
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Fact Sheet Technical Commentary
Fact Sheet Technical Commentary
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