What is imipramine for bipolar disorder?

Imipramine is a tricyclic antidepressant that is widely prescribed for both depression and anxiety. It works by increasing levels of serotonin and norepinephrine and by blocking certain serotonin, adrenergic, histamine, and cholinergic receptors.

What is the evidence for imipramine as treatment for bipolar disorder?

Low quality evidence is unable to determine the benefits of imipramine for bipolar disorder.

Review authors conclude that the existing evidence does not support the use of imipramine for bipolar disorder.

November 2021

Image: ©Unkas Photo-

Last updated at: 1:57 pm, 15th February 2022
To view documentation related to this topic download the files below
Fact Sheet Technical Commentary

NeuRA Libraries

Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.