How is neutropenia related to schizophrenia?

Clozapine is a second generation antipsychotic often administered when other antipsychotics are not affective. However, neutropenia is a potential side effect of clozapine use. Neutropenia can result in death and involves low levels of neutrophils; the white blood cells that help the body fight infection.

What is the evidence for neutropenia?

Moderate quality evidence suggests the incidence of mild neutropenia in people taking clozapine is around 3.8%, and the incidence of severe neutropenia is around 0.9%. Death from neutropenia is rare at around 0.013%.

October 2020

Last updated at: 4:07 am, 15th October 2020
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NeuRA Libraries

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