What is gabapentin treatment for bipolar disorder?

Gabapentin is an anticonvulsant used primarily in the treatment of seizure disorders such as epilepsy. Anticonvulsant medications influence the actions of neurotransmitters leading to a decrease in brain cell (neuron) excitability.

What is the evidence for gabapentin as a treatment for bipolar disorder?

Moderate to low quality evidence suggests no differences between gabapentin and placebo for the treatment of mania symptoms.

Low quality evidence is unable to determine differences between groups for treatment discontinuation; an indication of tolerability.

November 2021

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Last updated at: 1:28 pm, 15th February 2022
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