Gabapentin
What is gabapentin treatment for bipolar disorder?
Gabapentin is an anticonvulsant used primarily in the treatment of seizure disorders such as epilepsy. Anticonvulsant medications influence the actions of neurotransmitters leading to a decrease in brain cell (neuron) excitability.
What is the evidence for gabapentin as a treatment for bipolar disorder?
Moderate to low quality evidence suggests no differences between gabapentin and placebo for the treatment of mania symptoms.
Low quality evidence is unable to determine differences between groups for treatment discontinuation; an indication of tolerability.
November 2021
Image: ©cassis – stock.adobe.com
Last updated at: 1:28 pm, 15th February 2022
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Antecedents
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Illness course and outcomes
- Absconding
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Physical features
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Functional changes
- Body functioning
-
Biochemical changes
- Brain pH and lactate
- cAMP
- Cholesterol
- Dopamine
- Endocannabinoids
- GABA
- Hormonal changes
- Hypothalamic-pituitary-adrenal axis
- Infectious agents
- Inflammation and the immune system
- Lipids
- Neurometabolites
- Neurotrophins
- Nitric oxide
- NMDA receptor function
- Oxidative stress
- S100 Proteins
- Serotonin
- Synaptic proteins
- Trace elements
- Vascular endothelial growth factor
- Vitamin B
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- Cerebral blood flow and metabolism
- Electrophysiology
- Structural changes
- Brain regions
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Functional changes
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Co-occurring conditions
- Mental disorders
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Physical disorders
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- Cancer
- Cerebrovascular disease
- Dementia
- Dental disease
- Diabetes
- Digestive disorders
- Epilepsy
- Heart disease
- Infectious diseases
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- Obesity
- Optical alterations
- Peripheral vascular disease
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- Sexual dysfunction
- Skin disorders
- Sleep apnea
- Thyroid disorders
- Underweight
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Incidence and prevalence
- General
- Incidence
-
Prevalence
- Prevalence in children
- Prevalence in elderly people
- Prevalence in forensic settings
- Prevalence in homeless populations
- Prevalence in indigenous populations
- Prevalence in inpatients
- Prevalence in males vs. females
- Prevalence in migrants
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- Spatial variation in prevalence
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- General information
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Podcast Library
Title Colour Legend:
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Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.