How is fibromyalgia related to bipolar disorder?

People with bipolar disorder often have increased rates of co-occurring disorders, including fibromyalgia. Fibromyalgia is a centralised pain syndrome characterised by the presence of chronic widespread pain in association with fatigue, sleep disturbances and cognitive dysfunction. Fibromyalgia in people with bipolar disorder has been associated with higher rates of mood recurrences and greater disability. The use of antidepressants in fibromyalgia management may promote manic switches and episodes with mixed features, complicating the progressive course of bipolar disorder.

What is the evidence for comorbid fibromyalgia?

Moderate quality evidence suggests the overall prevalence of bipolar disorder in people with fibromyalgia is ~15%, with a large increased risk of bipolar disorder in people with fibromyalgia when compared to people without fibromyalgia.

April 2020

Last updated at: 2:13 am, 28th April 2020
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