Metabolic syndrome

How is metabolic syndrome related to bipolar disorder?

People with bipolar disorder often have increased rates of co-occurring disorders, including metabolic syndrome. Metabolic syndrome is defined by a clustering of at least three interrelated abnormalities including abdominal obesity, hyperglycemia, hypertension, high triglycerides, or low high-density lipoprotein (HDL) cholesterol levels. Metabolic syndrome increases the risk of diabetes and heart disease.

What is the evidence for comorbid metabolic syndrome?

Moderate to high quality evidence suggests the overall prevalence of metabolic syndrome in people with bipolar disorder is around 37%. Rates were highest in New Zealand, Australia and North America, in people treated with antipsychotics, and in older people. Compared to people without bipolar disorder matched to people with bipolar disorder for age and sex, there was a small increased risk of metabolic syndrome in people with bipolar disorder. Moderate to high quality evidence also shows a small increased risk of hypertension.

Moderate quality evidence suggests no significant differences in the rates of metabolic syndrome between people with bipolar disorder and people with schizophrenia or major depression.

May 2019

Last updated at: 2:29 am, 3rd May 2019
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