Premenstrual syndrome

How is premenstrual syndrome related to bipolar disorder?

Premenstrual syndrome involves emotional and behavioural symptoms that occur during the five days before menses for at least three menstrual cycles in a row. At least one affective and one somatic symptom must be present. Affective symptoms include depression, angry outbursts, irritability, anxiety, confusion, and social withdrawal. Somatic symptoms include breast tenderness, abdominal bloating, headache and swelling of extremities.

Women with bipolar disorder and premenstrual syndrome may experience exacerbation of mood symptoms during the premenstrual phase.

What is the evidence for premenstrual syndrome in women with bipolar disorder?

Moderate quality evidence suggests there is an association between premenstrual syndrome and higher risk of bipolar disorder and mood symptom exacerbation.

April 2019

Last updated at: 6:43 am, 9th April 2019
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