Wilson’s disease

How is Wilson’s disease related to bipolar disorder?

Wilson’s disease is rare disorder that prevents the body from eliminating copper. It is caused by mutations in a gene that results in an accumulation of the metal in the liver, central nervous system, kidneys and other organs. Wilson’s disease usually presents in childhood, but sometimes in adolescence or young adulthood, and may be accompanied by psychiatric symptoms.

What is the evidence for Wilson’s disease and bipolar disorder?

Moderate to low quality evidence suggests an increased risk of bipolar disorder, and to a lesser extent, major depressive disorder, in people with Wilson’s disease.

May 2020

Last updated at: 11:43 pm, 26th May 2020
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