Physical anomalies in relatives

How are physical anomalies relevant to relatives of people with bipolar disorder?

Relatives of people with bipolar disorder may show attenuated signs of the illness, such as physical features commonly identified with the disorder. These may include structural and/or functional anomalies as well as sleep disturbances.

What is the evidence for physical anomalies in relatives?

Moderate quality evidence suggests a medium-sized effect of lower amplitude of the sleep-wake cycle in people with bipolar disorder than in relatives.

Low quality evidence is unclear of brain anomalies in relatives of people with bipolar disorder compared to controls.

April 2019

Last updated at: 4:59 am, 8th April 2019
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