S100 proteins

What are S100 proteins?

S100 proteins are a subgroup of proteins which regulate intracellular processes such as cell growth and motility, cell cycle regulation, transcription and differentiation. They are characterised by two calcium binding sites of the helix-loop-helix conformation, and at least 21 members have been identified so far. S100B is one member of this subgroup that is primarily found in the cytoplasm of astrocytes. It regulates cell shape, energy metabolism, and intracellular signal transduction. Serum S100B has been used as a marker for CNS damage, particularly in astrocytes, as well as a marker of blood-brain-barrier disruption.

What is the evidence for S100 proteins in people with bipolar disorder?

Moderate quality evidence suggests a large effect of increased serum S100B in people with bipolar disorder during a mania phase compared to controls.

Moderate to low quality evidence suggests this effect is similar in people with bipolar disorder during any mood phase, and in people with major depression.

April 2019

Last updated at: 2:46 am, 9th April 2019
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NeuRA Libraries

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