Rheumatoid arthritis

How is rheumatoid arthritis related to risk for bipolar disorder?

Rheumatoid arthritis is a common systemic inflammatory disorder primarily affecting synovial joints. Peripheral inflammation can up-regulate neuroinflammation, inducing neurological damage that can affect mood and cognition. Chronic neuroinflammation has been proposed to be a contributory factor in the development of bipolar disorder, with studies demonstrating elevated inflammatory markers in people with bipolar disorder.

What is the evidence for rheumatoid arthritis as a risk factor for bipolar disorder?

Moderate quality evidence suggests a medium-sized increased risk of bipolar disorder in people with rheumatoid arthritis compared to people without rheumatoid arthritis.

June 2020

Last updated at: 2:04 am, 25th June 2020
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Fact Sheet Technical Commentary

NeuRA Libraries

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