Calcium channel blockers

How are calcium channel blockers relevant to bipolar disorder?

Calcium signalling has long been implicated in bipolar disorder, with reports of altered levels of calcium in people with mania, and the observation that long-term lithium treatment is associated with altered calcium metabolism. These reports prompted investigations of calcium channel blockers (primarily verapamil) as potential treatments for bipolar disorder.

What is the evidence for calcium channel blockers?

Moderate to low quality evidence suggests no differences between verapamil and placebo or lithium for manic symptoms or rates of discontinuation.

Low quality evidence is unable to determine side effects of any particular calcium channel blocker medications used by people with bipolar disorder.

March 2019

Last updated at: 5:13 am, 1st April 2019
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Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.