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What is asenapine?

The treatment of bipolar disorder is complex due to the presence of varying configurations of symptoms in patients. The primary treatments for bipolar disorder are pharmacological, and often involve second generation antipsychotic drugs, such as asenapine. Based on its high affinity for seratonin receptors, asenapine has been proposed as a treatment for bipolar disorder.

What is the evidence for asenapine as a treatment for bipolar disorder?

Moderate to high quality evidence suggests small to medium-sized effects of greater improvement in mania and depression symptoms with asenapine than with placebo. However, there were more extrapyramidal side effects, somnolence, dizziness, sedation, blood glucose, and weight gain with asenapine.

Moderate to high quality evidence suggests no differences between asenapine and olanzapine for mania symptoms. There was no analysis of depression symptoms. There was more dizziness and parkinsonism with asenapine, and more weight gain and higher prolactin levels with olanzapine.

April 2019

Last updated at: 4:50 am, 2nd April 2019
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Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.