What is paliperidone?

The treatment of bipolar disorder is complex due to the presence of varying configurations of symptoms in patients. The primary treatments for bipolar disorder are pharmacological, and often involve antipsychotic drugs such as the second-generation antipsychotic, paliperidone.

What is the evidence for paliperidone as treatment for bipolar disorder?

Moderate quality evidence suggests small to medium-sized effects of greater improvement in acute mania symptoms with paliperidone than with placebo or topiramate, although there was greater improvement with tamoxefin than with paliperidone. There was less all-cause discontinuation with paliperidone than with topiramate.

Moderate to low quality evidence suggests suggests there may be lower rates of somnolence with paliperidone than with quetiapine. There were also no consistent differences in rates of weight gain between paliperidone and placebo. Paliperidone may be more likely to elevate prolactin levels than placebo, quetiapine or olanzapine.

November 2021

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Last updated at: 2:01 pm, 1st December 2021
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