Brain structure

This category contains information on alterations in the brain structure of people with bipolar disorder.

Diffusion tensor imaging

What is diffusion tensor imaging (DTI)? DTI is a specialised imaging technique that uses MRI technology to investigate the movement of water within tissues of interest. It is a powerful imaging method for characterising the integrity of white matter circuitry because it links anatomical and functional neuroimaging. By applying a magnetic field, the movement (“diffusivity”) of water molecules can be visualised in vivo. The diffusion of water is influenced by the cellular structure of the surrounding tissues, and measures such as fractional anisotropy (FA) were derived as an approximate measurement for the freedom of movement. In areas of high structural…

Magnetic resonance imaging

What is magnetic resonance imaging (MRI)? MRI is based on the magnetisation properties of cellular protons. The application of a strong magnetic field causes the protons within cells to shift direction, which will return to their original position over time (“precession”). The rate of precession differs across tissue types (such as grey matter and white matter in the brain), which can be interpreted by specialised programs to represent a 3D image. What is the evidence for MRI findings in people with bipolar disorder? Grey matter decreases compared to controls High quality evidence shows small decreases in hippocampal subfields in people…

Telomere length

What is telomere length? Telomeres are protective caps on the ends of chromosomes. They are linked to aging as they shorten with each cell division, and when they reach a critical length the cell stops dividing or dies. Chronic stress has been associated with reduced telomere length, resulting in the recognition of an association between adverse social and environmental influences and accelerated aging. Bipolar disorder has also been associated with adverse environmental influences. What is the evidence for telomere length in people with bipolar disorder? Moderate to high quality suggests no differences in telomere length between people with bipolar disorder…

NeuRA Libraries

Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.