What is gamma-aminobutyric acid (GABA) in PTSD?

GABA is the most important inhibitor of neurotransmitters in the central nervous system and is often dysfunctional in people with mood disorders. It has also been investigated in people with PTSD. GABA can be measured via peripheral levels in plasma, via central levels in cerebrospinal fluid, and in brain regions using proton magnetic resonance spectroscopy.

What is the evidence for changes in GABA in people with PTSD?

Moderate to low quality evidence found no significant differences in brain GABA levels between people with PTSD and controls.

August 2021

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Last updated at: 6:11 pm, 9th December 2021
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NeuRA Libraries

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