Psychedelics

What are psychedelics?

High rates of treatment refractory PTSD has spurred a search for novel treatment approaches. One therapeutic candidate is 3,4-methylenedioxymethamphetamine (MDMA), which is an illicit psychedelic drug known for its widespread recreational use. By combining purified MDMA, rather than illicit “ecstasy” obtained from a non-medical setting, it facilitates therapeutic techniques, such as revisiting traumatic experiences with an appropriate level of emotional engagement. Through targeting multiple neurotransmitter systems, MDMA may offer pharmacologic advantages to SSRIs, which are restricted to a single neurotransmitter domain (serotonin).

What is the evidence on psychedelics for PTSD?

Moderate to low quality evidence found large improvements in symptoms, response, and remission with MDMA-assisted psychotherapy (supportive therapy) compared to placebo or low-dose MDMA.

August 2021

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Last updated at: 5:47 am, 28th July 2021
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NeuRA Libraries

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