Parietal lobe

What is the parietal lobe? 

The parietal cortex is located posterior to the frontal lobe. It is structurally divided into the superior, middle and inferior gyri. The most anterior portion of the parietal lobe forms the post-central gyrus, the somatosensory cortex. Posterior to this are the parietal association regions and the visual regions of the posterior parietal cortex involved in visuospatial processing.

What is the evidence for parietal lobe alterations?

Moderate quality evidence suggests grey matter reductions in the left inferior parietal gyrus in people with schizophrenia and bilateral post-central gyrus in people with chronic or first-episode schizophrenia compared to controls. Moderate to low quality evidence suggests reductions in white matter integrity in the parietal lobe, including temporo-parietal and parieto-occipital regions. High quality evidence suggests greater reductions over time in parietal white matter in people with schizophrenia than in controls.

Moderate quality evidence suggests reduced functional activation of the right inferior parietal lobe in people with schizophrenia during episodic memory encoding and executive functioning tasks. Regions of the inferior parietal cortex and precuneus show increased activity during executive functioning tasks. Moderate to low quality evidence suggests abnormal activity (mostly increased) in the parietal cortex of first-degree relatives of people with schizophrenia during cognitive control, working memory and language processing tasks. Moderate to low quality evidence shows decreased N-acetyl aspartate levels in parietal cortex grey matter in people with schizophrenia.

March 2019

Last updated at: 1:25 am, 29th March 2019
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