Adenosine modulators

What are adenosine modulators?

Adenosine modulates dopamine and glutamine which are both implicated in schizophrenia’s pathophysiology; therefore adenosine modulators may be useful adjunctive treatments for schizophrenia. Allopurinol is used for the treatment of gout and hyperuricemia; it inhibits purine degradation and subsequently increases adenosine levels. Dipyridamole and propentofylline inhibit cellular reuptake of adenosine and increases extracellular adenosine
concentration.

What is the evidence for adenosine modulators?

Moderate to low quality evidence suggests adjunctive adenosine modulators (particularly dipyridamole and propentofylline) may improve symptoms, particularly positive symptoms, in people with schizophrenia.

September 2019

Last updated at: 1:30 am, 11th September 2019
To view documentation related to this topic download the files below
Fact Sheet Technical Commentary

NeuRA Libraries

Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.