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What are analeptics? 

A supplementary, or adjunctive, treatment is administered in conjunction with a patient’s ongoing antipsychotic therapy. Analeptics, such as modafinil, have been suggested as potential adjunctive treatments for schizophrenia. Modafinal is a wake-promoting drug (mechanisms of action unknown) which is thought to help with the sedation side-effects of antipsychotics.

What is the evidence on adjunctive analeptics?

Moderate to high quality evidence suggests adjunctive modafinil or armodafinil may improve negative but not positive symptoms or cognition, with no adverse effects when compared to placebo. Lower quality evidence also finds no differences in global state, quality of life, hospitalisation rates, or study retention.

September 2020

Last updated at: 11:19 pm, 21st September 2020
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Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.