Anti-inflammatory medications

How are how are anti-inflammatory medications used for schizophrenia? 

Growing evidence suggests that inflammatory processes may contribute to the development of schizophrenia. This suggests a potential role for anti-inflammatory medications, such as non-steroidal agents (e.g., aspirin) which may be potentially useful therapeutic strategies, particularly in combination with ongoing antipsychotic medication.

What is the evidence for anti-inflammatory medications?

Moderate quality evidence suggests a small benefit of adjunctive aspirin for improving symptoms.

Moderate to low quality evidence suggests adjunctive oestrogen and adjunctive N-acetylcysteine may also improve symptoms.

Moderate quality evidence suggests a medium-sized benefit of adjunctive celecoxib for improving symptoms in first-episode patients, but not in chronic patients.

No effects were found for fatty acids, davunetide or minocycline.

March 2019

Last updated at: 10:14 pm, 20th March 2019
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