Serotonin modulators

What are serotonin modulators? 

Serotonin is a neurotransmitter. Atypical antipsychotics are thought to have some affinity for serotonin 5-HT receptors, for example clozapine, quetiapine, and olanzapine, among others. This suggests a potential for the use of serotonin-specific medications in the treatment of schizophrenia.

What is the evidence for adjunctive serotonin modulators?

Moderate to low quality evidence finds a large effect of greater improvement in overall symptoms with adjunctive buspirone compared to placebo, with no differences in adverse effects apart from fewer extrapyramidal symptoms with buspirone. There were no significant effectsof buspirone in the subgroup analyses of positive, negative and general symptoms or for cognition.

Moderate to low quality evidence also finds a large benefit for overall and negative symptoms with adjunctive granisetron, ondansetron, and tropisetron compared to placebo. There were no benefits of tandospirone for symptoms when compared to placebo.

October 2020

Last updated at: 11:26 pm, 30th September 2020
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