Serotonin modulators

What are serotonin modulators? 

Serotonin is a neurotransmitter. Atypical antipsychotics are thought to have some affinity for serotonin 5-HT receptors, for example clozapine, quetiapine, and olanzapine, among others. This suggests a potential for the use of serotonin-specific medications in the treatment of schizophrenia.

What is the evidence for adjunctive serotonin modulators?

Moderate quality evidence suggests a small effect of adjunctive buspirone, tandospirone, tropisetron, or mianserin for improving positive symptoms, and a medium-sized effect of buspirone or tandospirone for improving overall symptoms. Moderate to low quality evidence suggests a large effect for overall and negative symptoms with adjunctive granisetron, ondansetron, or tropisetron. No benefits are reported for cognitive functioning.

March 2019

Last updated at: 12:14 am, 21st March 2019
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Fact Sheet Technical Commentary

NeuRA Libraries

Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.