Treatments for dual diagnosis

What is dual diagnosis?

Dual diagnosis is the term used for people with both mental health and substance use disorders. Studies targeting this population often investigate outcomes relating to both diagnoses, such as symptoms, substance use, social function, quality of life, and cognitive outcomes.

What is the evidence for treatments for dual diagnosis?

Moderate to low quality evidence suggests olanzapine was superior to perphenazine, quetiapine, risperidone, and ziprasidone for overall symptoms in people with a dual diagnosis. Olanzapine was superior to perphenazine, quetiapine, and ziprasidone for positive symptoms, and olanzapine was superior to perphenazine, risperidone, and ziprasidone for negative symptoms.

The remaining evidence on antipsychotics and other agents (e.g. mazindol, lamotrigine, antidepressants, anti-craving agents, or disulfiram) for symptoms, substance use or other outcomes was based on small sample sizes, so no conclusions can be drawn.

October 2020

Last updated at: 3:41 am, 8th October 2020
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Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.