Treatments for hyperprolactinaemia

What is hyperprolactinemia?

One potential side effect of antipsychotic use is hyperprolactinaemia, which can disrupt sex hormones and the production and flow of breast milk, and can cause infertility and erectile dysfunction in men. Hyperprolactinaemia is caused by blocking of the D2 dopamine receptor at the anterior lobe of the pituitary gland, resulting in high prolactin levels. As different antipsychotics have different actions, they also differ in the degree to which they affect prolactin levels.

What is the evidence for treatments for hyperprolactinaemia?

Moderate quality evidence shows a benefit of adjunctive metaformin for reducing serum prolactin levels in people with schizophrenia taking antipsychotics. Note that all trials were conducted in China, so these results may not apply to other populations.

October 2020

Last updated at: 4:44 am, 8th October 2020
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