Topics tagged with "Estrogen"

Estrogen modulators

What is estrogen for bipolar disorder? Tamoxifen is a selective estrogen-receptor modulator that is used to treat breast cancer. Studies on the pathophysiology of bipolar disorder have demonstrated abnormalities in protein kinase C (PKC) signaling in manic states. Inhibition of PKC can result in antimanic effects. Currently, tamoxifen is the only relatively specific PKC inhibitor that is available for human use and that is capable of crossing the blood-brain barrier. What is the evidence for tamoxifen? Moderate quality evidence suggests large effects of greater improvement in acute mania symptoms with tamoxefin than with placebo, risperidone, haloperidol, olanzapine, caripraxine, lithium, carbamazepine,…

Hormonal changes

What are hormones and how do they relate to schizophrenia? Hormones are chemical messengers secreted by the endocrine glands. Hormones travel through the bloodstream to tissues and organs, and control most of the body’s major systems including heart rate, metabolism, mood, sexual function, and growth and development. Neuroactive steroids, including testosterone, dehydroepiandrosterone and its sulphide ester, are important for brain development as they influence synaptic connectivity and neuronal differentiation. Thyroid hormones also play a role in neurodevelopmental processes, such as differentiation of neural cells, synaptogenesis, and myelination. Prolactin is involved in many biological functions including reproduction, pregnancy and lactation, and…

NeuRA Libraries

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