Topics tagged with "Relapse"


How is relapse determined? People with bipolar disorder may relapse with manic, mixed, or depressive episodes, regardless of what their previous episode involved. The chance of relapse is complicated by differential response to treatments and other factors associated with the disorder. Preventing the development of rapid cycling symptoms is particularly paramount to good outcomes. What is the evidence for relapse in people with bipolar disorder? Moderate to high quality evidence suggests there were more major life events occurring just prior to a mood episode than prior to an euthymic, stable phase of the disorder, indicating transitions and major life changes…

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Medication for relapse prevention

How are medications related to relapse? Bipolar disorder is a disabling condition characterised by episodes of mania or hypomania and depression. Adherence to pharmacological treatment is critical for effective control of symptoms and to prevent relapse. What is the evidence for pharmaceutical treatments for relapse prevention? Overall, moderate to high quality evidence finds maintaining antipsychotic or mood stabiliser treatment is associated with fewer relapses than discontinuing antipsychotic or mood stabiliser treatment. Medications compared to placebo Moderate quality evidence finds the following medications reduced overall relapse rates more than placebo (in descending order of effectiveness); asenapine, aripiprazole + valproate, lithium +…

Assessment tools

Medications for relapse prevention

What is relapse prevention for schizophrenia? Studies have shown that about 80% of patients relapse to psychosis within 5 years of initial diagnosis. Antipsychotic drugs have played a central role in the treatment of schizophrenia for more than 50 years and antipsychotic use significantly reduces the risk of relapse. What is the evidence for relapse prevention? High quality evidence shows a small benefit of specialist first-episode psychosis programs (involving both psychosocial and pharmaceutical treatments) for reducing the risk of relapse and less all-cause discontinuation of treatment compared to treatment as usual. These programs may also reduce the length of hospital…

Psychotic relapse

What is psychotic relapse? Psychotic relapse is the reoccurrence of previously treated psychotic symptoms.  Effective early recognition may offer the potential for early intervention to prevent relapse, such as medication adjustment, psychosocial treatments, social support and stress reduction. Early warning signs are subjective experiences, thoughts and behaviours that occur immediately prior to a psychotic relapse, which signal to the patient or their family that their condition is deteriorating. It is important that these early signs be identifiable by family members or carers, as patients may minimise or disguise these symptoms in order to appear healthy or to avoid hospital readmission….

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