What is clozapine?

The treatment of bipolar disorder is complex due to the presence of varying configurations of symptoms in patients. The primary treatments for bipolar disorder are pharmacological, and often involve second generation antipsychotic drugs, such as clozapine. Based on its high affinity for both serotonin and dopamine receptors, clozapine has been proposed as a treatment for bipolar disorder.

What is the evidence for clozapine as treatment for bipolar disorder?

Moderate to low quality evidence suggests improved symptoms and reduced hospitalisation, suicidal ideation, and aggressive behaviour, and also improved social functioning with clozapine in people with treatment-resistant bipolar disorder.

July 2020

Last updated at: 11:03 pm, 6th July 2020
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