GABA agonists

What are GABA-acting medications?

GABA (gamma-aminobutyric acid) is a common neurotransmitter in the brain, and GABA-ergic neurons are thought to interact with antipsychotic medications, contributing to side effects such as tardive dyskinesia. GABA-acting medications, such as baclofen, progabide, or sodium valproate, may contribute to increasing the activity of GABA neurons, potentially leading to reduced medication side effects. Adjunct medications prescribed to treat side effects of antipsychotic medication may contribute to increasing adherence to these medications, and reduce the risk of psychotic relapse.

What is the evidence for GABA-acting medications?

Moderate quality evidence suggests no significant benefit of GABA-acting medications for mental state, tardive dyskinesia, or study attrition, and no differences between treatment and placebo in adverse effects.

March 2019

Last updated at: 11:48 pm, 20th March 2019
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Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.