GABA agonists

What are GABA-acting medications?

GABA (gamma-aminobutyric acid) is a common neurotransmitter in the brain, and GABA-ergic neurons are thought to interact with antipsychotic medications, contributing to side effects such as tardive dyskinesia. GABA-acting medications, such as baclofen, progabide, or sodium valproate, may contribute to increasing the activity of GABA neurons, potentially leading to reduced medication side effects. Adjunct medications prescribed to treat side effects of antipsychotic medication may contribute to increasing adherence to these medications, and reduce the risk of psychotic relapse.

What is the evidence for GABA-acting medications?

Moderate quality evidence suggests a small benefit of GABA-acting agents for tardive dyskinesia, with no benefits for mental state or study retention. There may be more sedation and dizziness with GABA-acting agents than with placebo.

September 2019

Last updated at: 5:59 am, 23rd September 2019
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NeuRA Libraries

Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.