Our response to COVID-19

We're supporting people to maintain their wellbeing and manage isolation.

Treatments for social functioning

What are social functioning treatments?

Poor social and interpersonal skills can prevent people from interacting effectively with other people. Psychosocial programs targeting the improvement of social skills are designed to allow people to achieve greater social and community functioning. Antipsychotics may also improve social skills.

What is the evidence for pharmaceutical effects on social functioning?

Moderate to high quality evidence (in order of descending effects, first being best), found improvements in social functioning with thioridazine, olanzapine, paliperidone, quetiapine, lurasidone, and brexpiprazole compared to placebo. There were no improvements with aripiprazole, sertindole, amisulpride, ziprasidone, flupentixol, and risperidone

For side effects (in order of first being best), there was a large effect of less use of antiparkinson drugs with clozapine, and more use of antiparkinson drugs with paliperidone, ziprasidone, risperidone, lurasidone, zotepine, cariprazine, chlorpromazine, sulpiride, perphenazine, molindone, zuclopenthixol, trifluoperazine, flupentixol, haloperidol, loxapine, penfluridol, fluphenazine, chlorpromazine, thiotixene and pimozide. There was more akathisia with aripiprazole, ziprasidone, thioridazine, asenapine, amisulpride, chlorpromazine, thiotixene, risperidone, cariprazine, loxapine, haloperidol, lurasidone, trifluoperazine, sulpiride, molindone, penfluridol, pimozide, fluphenazine, flupentixol, and zuclopenthixol. There was more weight gain with haloperidol, amisulpride, asenapine, risperidone, paliperidone, clozapine, quetiapine, iloperidone, chlorpromazine, sertindole, olanzapine, and zotepine. There was less prolactin elevation with aripiprazole, clozapine, and zotepine, and more prolactin elevation with olanzapine, asenapine, lurasidone, sertindole, haloperidol, amisulpride, risperidone, and paliperidone. There was more sedation with aripiprazole, lurasidone, haloperidol, risperidone, asenapine, loxapine, olanzapine, chlorpromazine, thioridazine, thiotixene, ziprasidone, perazine, clozapine, clopenthixol, quetiapine, sulpiride, zotepine, and zuclopenthixol. There was more QTc prolongation with quetiapine, olanzapine, risperidone, iloperidone, ziprasidone, amisulpride, and sertindole.

October 2020

Last updated at: 11:06 pm, 5th October 2020
To view documentation related to this topic download the files below
Fact Sheet Technical Commentary

NeuRA Libraries

Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.